30 Kasım 2007
29 Kasım 2007
edirne'den sevgiler
Merhaba abi,sayfan çok güzel olmuş,çok beğendim.Espiyemizin güzelliklerinden bahsedersen ve görüntüler yayınlarsan çok daha güzel olur,öpüyorum grş
24 Kasım 2007
17 Kasım 2007
VATAN BÖLÜNMEZ
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KADIN HASTALIKLARI VE DOĞUM UZMANI
Serkan Kahyaoglu
BREAST CANCER
Breast Cancer Risk Associated With BRCA1 and BRCA2 in Diverse Populations
Posted 12/19/2007
James D. Fackenthal; Olufunmilayo I. Olopade
Abstract and Introduction
AbstractGermline mutations in the BRCA1 or BRCA2 tumour-suppressor genes are strong predictors of breast and/or ovarian cancer development. The contribution of these mutations to breast cancer risk within any specific population is a function of both their prevalence and their penetrance. Mutation prevalence varies among ethnic groups and may be influenced by founder mutations. Penetrance can be influenced by mutation-specific phenotypes and the potential modifying effects of the patient's own genetic and environmental background. Although estimates of both mutation prevalence and mutation penetrance rates are inconsistent and occasionally controversial, understanding them is crucial for providing accurate risk information to each patient
Posted 12/19/2007
James D. Fackenthal; Olufunmilayo I. Olopade
Abstract and Introduction
AbstractGermline mutations in the BRCA1 or BRCA2 tumour-suppressor genes are strong predictors of breast and/or ovarian cancer development. The contribution of these mutations to breast cancer risk within any specific population is a function of both their prevalence and their penetrance. Mutation prevalence varies among ethnic groups and may be influenced by founder mutations. Penetrance can be influenced by mutation-specific phenotypes and the potential modifying effects of the patient's own genetic and environmental background. Although estimates of both mutation prevalence and mutation penetrance rates are inconsistent and occasionally controversial, understanding them is crucial for providing accurate risk information to each patient